Omotola popularly known as "Omosexy" was born in a family of five to Mr. & Mrs. Shola Jalade (both late) and two brothers, Tayo and Bolaji Jalade. She attended Christland Nursery School Opebi and Oxford Children School, Santos Layout; both in Lagos. She proceeded to Kaduna for her Secondary Education at Command Secondary School . She is currently undertaking a Higher National Diploma (HND) course in Estate Management at Yaba College of Technology, Lagos.

She joined the movie industry in 1995 and was first featured in the movie "Venom of Justice". However, "Mortal Inheritance", also in 1995 shot her to stardom. Besides acting, she also sings and has released two albums. She features as a writer for the Saturday SUN (Omotola's Diary) and occasionally gets involved in Social Services for women and charity homes. Omotola Jalade Ekehinde is a beautiful award winning actress known for her craft all around Africa. This screen goddess within the space of 10 years, has been able to play major roles in numerous movies. Omotola radiates the aura of a real star. The A-list actress has won several local and international awards.

She got married to Capt. Matthew Ekeinde at the Ikeja registry on the 23rd, March 1996, and had a beautiful white wedding on board a DASH 7 Aircraft flying from Lagos to Benin, on the 19th April, 2001. They are blessed with four children; two sons and two daughters.